Author: Jenny Fernandez

Paper Trail: Uterine bleeding in transmasculine and nonbinary teens, opioids for severe abdominal pain, status epilepticus and more

Latest clinical research from Boston Children's

Boston Children’s Hospital is at the forefront of clinical research. Stay connected with Paper Trail — a monthly feature highlighting recently published outcomes data and new approaches to the diagnosis, treatment and prevention of pediatric illnesses.

Status epilepticus: Should we treat it like stroke?

Status epilepticus, a state of prolonged seizures, is one of the most common pediatric neurologic emergencies, affecting 10-20% of pediatric epilepsy patients. A new study published in JAMA Neurology underscores the point that rapid treatment improves outcomes and may save lives. “Status epilepticus should be considered a time-sensitive emergency, such as a stroke or other cardiovascular events,” says Tobias Loddenkemper, MD, senior author and director of clinical epilepsy research at Boston Children’s.

Pain management in pediatric acute pancreatitis: Opioid vs. non-opioid

Nearly all patients with acute pancreatitis (AP) experience some degree of severe abdominal pain, yet strategies for pain management in AP have been poorly studied, particularly in the field of pediatrics. Gastroenterology researcher Amit Grover, MD examines the initial provision of analgesia to children who presented to a pediatric emergency department with AP. Learn more in this Journal of Pediatric Gastroenterology and Nutrition paper.

Persistent uterine bleeding in transmasculine and nonbinary teens

The treatment of persistent uterine bleeding can be difficult in a subset of patients who identify as transmasculine or nonbinary. In this recent Transgender Health article, endocrinology researchers Stephanie Roberts, MD and Jeremi Carswell, MD review the physiology of the normal menstrual cycle and the hormonal influences on the endometrium, and explore options for the treatment of persistent bleeding for people both already on testosterone and for those who are either not ready for or who do not desire testosterone.

A practical approach to severe asthma in children

Severe asthma accounts for only a small proportion of the children with asthma, but a disproportionately high amount of resource utilization and morbidity. In a new Annals of the American Thoracic Society paper, senior author and pulmonology researcher Jonathan Gaffin, MD describes the importance of an evidence-based, multidisciplinary approach to treating severe asthma.

For more clinically-actionable insights, bookmark Boston Children’s Notes blog for primary care providers.

Multidisciplinary care to treat severe asthma

Multidisciplinary care for severe asthma

The Severe Asthma Program at Boston Children’s Hospital provides care to children and young adults with severe persistent asthma who have difficulty with disease management or chronic systemic steroid use. “We’ve developed a one-stop shop for the highest risk, highest cost, highest morbidity population of pediatric asthma,” says pulmonologist Jonathan Gaffin, MD, MMSc, who conceived of the program after witnessing hundreds of patients crossing between Boston Children’s Division of Pulmonary Respiratory Diseases and Division of Allergy and Immunology…Read More

Challenging cases: Managing chronic lung disease after stem cell transplant

Helping our patients survive and thrive after stem cell transplant.It’s Donate Life Month, and at Boston Children’s Hospital’s Division of Pulmonary and Respiratory Diseases, we’re focused on helping our lung transplant recipients survive and thrive year-round.

We give these most critically ill children the best chance by working across disciplines to develop a long-term care plan, using new and innovative therapies when available. We are one of the few pediatric centers to offer photopheresis, a therapy that has been beneficial in treating graft vs. host disease (GVHD) and graft rejection in lung transplantation.

Craig Gerard, MD, PhD and team manage a challenging case.
Craig Gerard, MD, PhD

“As many stem cell transplant (SCT) patients later battle chronic lung disease, they are well served by our integrated team approach involving specialists in pulmonology, endocrinology and dermatology as well as experts in oncology from Dana Farber/Boston Children’s Cancer and Blood Disorders Center,” says Craig Gerard, MD, PhD, chief of the Division of Respiratory Diseases and the Leila and Irving Perlmutter Professor of Pediatrics.

Read the case of a patient treated with a bilateral lung transplant for pulmonary complications after SCT for refractory acute lymphoblastic leukemia who is now thriving.

…Read More

Innovations and advancements: Honoring American Heart Month

We celebrate American Heart Month every February by doing what we do every day: treating a full spectrum of cardiac disorders and creating new ways to improve care.

This month, we also honor our patients, raise awareness around pediatric heart conditions and give thanks to Boston Children’s Heart Center faculty who are committed to finding solutions and serving every patient’s needs — no matter how complex the condition or situation.

Read a selection of five stories from the past year that highlight some of the Heart Center’s recent innovations and advancements. …Read More