Paper Trail: Uterine bleeding in transmasculine and nonbinary teens, opioids for severe abdominal pain, status epilepticus and more

Latest clinical research from Boston Children's

Boston Children’s Hospital is at the forefront of clinical research. Stay connected with Paper Trail — a monthly feature highlighting recently published outcomes data and new approaches to the diagnosis, treatment and prevention of pediatric illnesses.

Status epilepticus: Should we treat it like stroke?

Status epilepticus, a state of prolonged seizures, is one of the most common pediatric neurologic emergencies, affecting 10-20% of pediatric epilepsy patients. A new study published in JAMA Neurology underscores the point that rapid treatment improves outcomes and may save lives. “Status epilepticus should be considered a time-sensitive emergency, such as a stroke or other cardiovascular events,” says Tobias Loddenkemper, MD, senior author and director of clinical epilepsy research at Boston Children’s.

Pain management in pediatric acute pancreatitis: Opioid vs. non-opioid

Nearly all patients with acute pancreatitis (AP) experience some degree of severe abdominal pain, yet strategies for pain management in AP have been poorly studied, particularly in the field of pediatrics. Gastroenterology researcher Amit Grover, MD examines the initial provision of analgesia to children who presented to a pediatric emergency department with AP. Learn more in this Journal of Pediatric Gastroenterology and Nutrition paper.

Persistent uterine bleeding in transmasculine and nonbinary teens

The treatment of persistent uterine bleeding can be difficult in a subset of patients who identify as transmasculine or nonbinary. In this recent Transgender Health article, endocrinology researchers Stephanie Roberts, MD and Jeremi Carswell, MD review the physiology of the normal menstrual cycle and the hormonal influences on the endometrium, and explore options for the treatment of persistent bleeding for people both already on testosterone and for those who are either not ready for or who do not desire testosterone.

A practical approach to severe asthma in children

Severe asthma accounts for only a small proportion of the children with asthma, but a disproportionately high amount of resource utilization and morbidity. In a new Annals of the American Thoracic Society paper, senior author and pulmonology researcher Jonathan Gaffin, MD describes the importance of an evidence-based, multidisciplinary approach to treating severe asthma.

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