Stories about: antibiotics

Effective use of antibiotics starts with a complete allergy history

Effective antibiotic use starts with allergy history
PHOTO: ADOBE STOCK

This week is Antibiotic Awareness Week, a week focused on using antibiotics appropriately to provide the best clinical outcomes and avoid antibiotic resistance.

As physicians who care for patients with antibiotic resistant infections and those with antibiotic allergies, we know that there are real clinical advantages to being able to use “narrow” beta-lactam antibiotics such as amoxicillin. In fact, for many diagnoses, patients have better outcomes when they are treated with beta-lactam antibiotics that are targeted to their specific bacteria.  …Read More

ResistanceOpen: Mapping antibiotic resistance in the US

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In April 2014, the World Health Organization (WHO) released a global report highlighting the increase in worldwide antibiotic resistance and warning the public of a “post-antibiotic era“. The WHO report gathered data from 129 member states and found that antimicrobial resistance existed in every region of the globe.

A year prior, the Centers for Disease Control (CDC) published a similar report regarding antibiotic resistance in the U.S. It estimated there are approximately 2 million illnesses and 23,000 deaths caused by antibiotic resistant bacteria or fungi in the U.S. every year. Both reports represent a major warning: resistance is happening, it is widespread, and it extends to include “last resort” antibiotics.

Over the last 20 years, the rate of resistance to infections has skyrocketed from 10 to 15 percent in the 1990s to 60 percent today. Simultaneously, pharmaceutical companies have stopped investing in the development of antibiotics.  Only 11 new antibiotics were introduced between 1998 and 2014, and the last class of antibiotics in was approved in 1987 — 29 years ago.

Derek MacFadden, MD, a research fellow at Boston Children’s Hospital, and his project ResistanceOpen, hope to fight the seemingly impending post-antibiotic era. …Read More