Stories about: asthma

Paper Trail: Uterine bleeding in transmasculine and nonbinary teens, opioids for severe abdominal pain, status epilepticus and more

Latest clinical research from Boston Children's

Boston Children’s Hospital is at the forefront of clinical research. Stay connected with Paper Trail — a monthly feature highlighting recently published outcomes data and new approaches to the diagnosis, treatment and prevention of pediatric illnesses.

Status epilepticus: Should we treat it like stroke?

Status epilepticus, a state of prolonged seizures, is one of the most common pediatric neurologic emergencies, affecting 10-20% of pediatric epilepsy patients. A new study published in JAMA Neurology underscores the point that rapid treatment improves outcomes and may save lives. “Status epilepticus should be considered a time-sensitive emergency, such as a stroke or other cardiovascular events,” says Tobias Loddenkemper, MD, senior author and director of clinical epilepsy research at Boston Children’s.

Pain management in pediatric acute pancreatitis: Opioid vs. non-opioid

Nearly all patients with acute pancreatitis (AP) experience some degree of severe abdominal pain, yet strategies for pain management in AP have been poorly studied, particularly in the field of pediatrics. Gastroenterology researcher Amit Grover, MD examines the initial provision of analgesia to children who presented to a pediatric emergency department with AP. Learn more in this Journal of Pediatric Gastroenterology and Nutrition paper.

Persistent uterine bleeding in transmasculine and nonbinary teens

The treatment of persistent uterine bleeding can be difficult in a subset of patients who identify as transmasculine or nonbinary. In this recent Transgender Health article, endocrinology researchers Stephanie Roberts, MD and Jeremi Carswell, MD review the physiology of the normal menstrual cycle and the hormonal influences on the endometrium, and explore options for the treatment of persistent bleeding for people both already on testosterone and for those who are either not ready for or who do not desire testosterone.

A practical approach to severe asthma in children

Severe asthma accounts for only a small proportion of the children with asthma, but a disproportionately high amount of resource utilization and morbidity. In a new Annals of the American Thoracic Society paper, senior author and pulmonology researcher Jonathan Gaffin, MD describes the importance of an evidence-based, multidisciplinary approach to treating severe asthma.

For more clinically-actionable insights, bookmark Boston Children’s Notes blog for primary care providers.

Multidisciplinary care to treat severe asthma

Multidisciplinary care for severe asthma

The Severe Asthma Program at Boston Children’s Hospital provides care to children and young adults with severe persistent asthma who have difficulty with disease management or chronic systemic steroid use. “We’ve developed a one-stop shop for the highest risk, highest cost, highest morbidity population of pediatric asthma,” says pulmonologist Jonathan Gaffin, MD, MMSc, who conceived of the program after witnessing hundreds of patients crossing between Boston Children’s Division of Pulmonary Respiratory Diseases and Division of Allergy and Immunology…Read More

In the pipeline: New therapies to manage severe therapy-resistant asthma

Pediatric Asthma - Girl blowing a dandelion

Over seven million children in the U.S. have been diagnosed with asthma. Many patients only experience mild, intermittent symptoms and can be treated symptomatically with medicines like Abluterol. Most of the remaining patients can achieve good asthma control by using daily medicines to decrease inflammation in the lung.

However, about 10 percent of children with asthma have difficult-to-treat disease. The challenge is identifying new therapies for these patients so they may live free of daily symptoms or the fear of exacerbations.

…Read More

QuickNote: Does Tylenol really make asthma symptoms worse?


New research on Tylenol and asthma may surprise you

You may have heard that acetaminophen (Tylenol) can exacerbate asthma in children, and that alternative medications should be given to children with asthma when they experience pain or fever. A new study refutes this widely-held belief, and finds no correlation between Tylenol and increased asthma symptoms in children.

The study, published last week in The New England Journal of Medicine, followed 300 children 1 – 5 years old with mild persistent asthma from 18 health care institutions. The patients were randomly divided into two groups: one was told to use acetaminophen as indicated for pain or fever, and the other was told to use ibuprofen. The study was conducted over a 48-week period.

During the nearly seven week follow-up period, researchers found no statistically significant difference in asthma rates or severity between the two groups.

Read the full text in The New England Journal of Medicine.