Interest in gluten—and in particular, avoiding it — continues to be on the rise. The gluten-free market has become a billion dollar business as more and more adults and children trial this restrictive diet. Many go gluten-free as a lifestyle choice.
However, many turn to a gluten-free diet for medical reasons and for relief of specific symptoms. It is estimated that roughly 10 percent of the population have gluten-related disorders. Figuring out whether an individual needs to be gluten-free and where she lies on the spectrum of gluten-related disorders can be hard, but is an important endeavor. …Read More
Diagnosing pediatric celiac disease, an autoimmune enteropathy triggered by ingestion of gluten (found in wheat, rye, barley and standard oats), can be challenging. Despite its high prevalence, effecting approximately 1 percent of the population, many cases go unrecognized.
Presenting signs and symptoms of pediatric celiac disease are varied, ranging from gastrointestinal symptoms such as abdominal pain, diarrhea or constipation to extraintestinal symptoms, such as low energy, poor growth or delayed puberty. Symptoms can be subtle, intermittent or nonexistent. High-risk children include those with autoimmune disease (such as type 1 diabetes mellitus and thyroid disease) and with a family member with celiac disease.
Identifying which children need testing for celiac disease is the first step but is not the only part of the evaluation that can get complicated. Positive celiac serology, such as tissue transglutaminase IgA and endomysial IgA, are typically excellent predictors of celiac disease diagnosis. However, it is important to remember that children without celiac disease can have positive test results. For this reason, small bowel biopsy via esophagogastroduodenoscopy (EGD) before starting a gluten free diet, is still the gold standard for diagnosing celiac disease. …Read More